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KMID : 0043319920150030204
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Archives of Pharmacal Research
1992 Volume.15 No. 3 p.204 ~ p.207
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Designing of Antiepileptic Ligands by Esterification and Acetylation of Dipeptides
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Vishwakarma KK
Saraf SK/Uppadhyay RK/Kohli DV
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Abstract
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Glycylglycine, alanylalanine and alanylglycine were synthesized, their free carboxylic and amino groups were converted to methyl esters of N-acetylglycylglycine, N-acetylalanylglycine and N-acetylalanylalanine. The synthesized compounds were evaluated for antiepileptic activity, plasmaprotein binding, TD50 and potentiating effect of phenobarbitone sodium.
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